Yes, yes I do. Biggest piece of shit key on the keyboard. There are less useful ones, but none as completely annoying for their placement. Here are some nifty tricks to disable this terrible key.

Windows 2000/XP:
Check out this page. You will find registry keys to remap the Caps Lock key as a Shift key, change Caps Lock into a Control key, swap the Caps Lock and the left Control key, or uninstall any of these Registry changes you may have made.

Mac OS X 10.4
Check out this handy page. You can actually disable the caps lock key using the Keyboard & Mouse preferences pane. Word.